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Patient-centered research for better health and healthcare

Susan Solymoss

     Current academic and hospital titles
     
      Associate Professor
      Medicine and Oncology
      McGill University

      Director
      Division of Hematology
      St. Mary's Hospital Centre

      Email

 

 

 

Current research interests

Treatment and prevention of venous thromboembolism.
Clinical and laboratory risk factors related to disease evolution.
Risk stratification and disease management of patients with thromboembolic disease.

Current and recent research grants and collaborations

A phase III randomised, double blind, parallel-group study of the efficacy and safety of oral dabigatran etexilate (150 mg bid) compared to warfarin (INR 2.0-3.0) for 6 month treatment of acute symptomatic venous thromboembolism, following initial treatment 95-10 days) with a parenteral anticoagulant approved for this indication. RE-COVER
Funded by: Boehringer Ingelheim - Principal Investigator Dr. Sam Shulman
 
TIPPS Study Thrombophilia in pregnancy complications.
Funded by: Canadian Heart and Stroke Foundation - Principal Investigator Dr. Marc Rodger
 
The SOX Trial: Compression Stockings to prevent the post-thrombotic syndrome.
Funded by: CIHR - Principal Investigator Dr. Susan Kahn
 
Recent publications

Kahn SR, Shapiro S, Wells PS, Rodger MA, Kovacs MJ, Anderson DR, Tagalakis V, Houweling AH, Ducruet T, Holcroft C, Johri M, Solymoss S, Miron MJ, Yeo E, Smith R, Schulman S, Kassis J, Kearon C, Chagnon I, Wong T, Demers C, Hanmiah R, Kaatz S, Selby R, Rathbun S, Desmarais S, Opatrny L, Ortel TL, Ginsberg JS; SOX trial investigatores. Lancet, 383(9920):880-888, March 2014.

Gándara E, Kovacs JM, Kahn SR, Wells PS, Anderson DA, Chagnon I, Le Gal G, Solymoss S, Crowther M, Carrier M, Langlois N, Kavacs J, Little Ma J, Carson N, Ramsay T, Rodger MA. Non-OO blood type influences the risk of recurrent venous thromboembolism. A cohort study. Thromb Haemost; 110(6):1172-1179, Dec 2013.

Galanaud JP, Holcroft CA, Rodger MA, Kovacs MJ, Betancourt MT, Wells PS, Anderson DR, Chagnon I, Le Gal G, Solymoss S, Crowther MA, Perrier A, White RH, Vickars LM, Ramsay T, Kahn SR. Predictors of post-thrombotic syndrome in a population with a first deep vein thrombosis and no primary venous insufficiency. Journal of Thrombosis and Haemostatis. 11(3):474-480, 2013.

Gauthier K, Kovacs MJ, …Wells PS, Kahn SR, Anderson DA,  Chagnon I, Solymoss S, Crowther M, White RS, Perrier A, Vickers L, Carrier M, Sabris E. Family history of venous thromboembolism (VTE) as a predictor for recurrent VTE in unprovoked VTE patients. Journal of Thrombosis and Haemostasis.  11(1): 200-203, 2013.

Chitsike RS, Rodger MA, Kovacs MJ, Betancourt MT, Wells PS, Anderson DR, Chagnon I, Le Gal G, Solymoss S, Crowther MA, Perrier A, White RH, Vickars LM, Ramsay T, Kahn SR.  Risk of post-thrombotic syndrome after subtherapeutic warfarin anticoagulation for a first unprovoked deep vein thrombosis: results from the REVERSE study. Journal of Thrombosis and Haemostasis. 10(10):2039-2044, 2012.

Galanaud JP, Holcroft CA, Rodger MA, Kovacs MJ, Betancourt MT, Wells PS, Anderson DR, Chagnon I, Le Gal G, Solymoss S, Crowther MA, Perrier A, White RH, Vickars LM, Ramsay T, Kahn SR. Comparison of the Villalta post thrombotic syndrome score in the ipsilateral versus the contralateral leg after a first unprovoked deep vein thrombosis. Journal of Thrombosis and Haemostatis. 10(6):1036-1042, 2012.

Kahn SR, Johri M, Houweling AH, Holcroft C, Solymoss S. A multicenter randomized placebo controlled trial of compression stockings to prevent the post-thrombotic syndrome after proximal deep venous thrombosis: The SOX trial. Blood. 120(21), 2012.

Levine MN, Gu C, Liebman HA, Escalante CP, Solymoss S, Deitchman D, Ramirez L, Julian J. A randomized phase II trial of apixaban for the prevention of thromboembolism in patients with metastatic cancer. Journal of Thrombosis and Haemostatis. 10(5):807-814, 2012.

Solymoss S. Risk of venous thromboembolism with oral contraceptives. Canadian Medical Association Journal. 183(18):E1278-E1279, 2011.

Chitsike, Rufaro S, Kahn SR, Kovacs MK, Betancourt MT, Wells PS, Anderson D, Chagnon I, Solymoss S, et al. Relationship between subtherapeutic warfarin anticoagulation and the development of post thrombotic syndrome after a first unprovoked deep vein thrombosis: results from the REVERSE cohort study. Blood. 118(21):324, 2011.

Dieudé M, Correa JA, Neville C, Pineau C, Levine JS, Subang R, Landolt-Marticorena C, Su J, Kassis J, Solymoss S, Fortin PR, Rauch J. Association of autoantibodies to heat-shock protein 60 with arterial vascular events in patients with antiphospholipid antibodies. Arthritis and Rheumatism. 63(8): 2416-2424, 2011.

Esfahani K, Gold P, Wakil S, Michel RP, Solymoss S. Acute liver failure because of chronic lymphocytic leukemia: case report and review of the literature. Current Oncology. 18(1):39-42, 2011.

Guanella R, Ducruet T, Johri M, Miron MJ, Roussin A, Desmarais S,  Joyal F, Kassis J, Solymoss S, Ginsberg JS, Lamping DL, Shrier I, Kahn SR. Economic burden and cost determinants of deep vein thrombosis during 2 years following diagnosis: a prospective evaluation. Journal of Thrombosis and Haemostasis.  9(12):2397-2405, 2011.

Le Gal G, Carrier M, Kovacs MJ, Betancourt MT, Kahn SR, Wells PS, Anderson DA, Chagnon I, Solymoss S, Crowther M, Righini M, Delluc A, White RH, Vickars L, Rodger M. Residual vein obstruction as a predictor for recurrent thromboembolic events after a first unprovoked episode: date from the REVERSE cohort study. Journal of Thrombosis and Haemostatis. 9(6):1126-1132, 2011.

Rodger MA, Kekre N, Le Gal G, Kahn SR, Wells PS, Anderson DA, Chagnon I, Solymoss S, Crowther M, Perrier A, White R, Vickars L, Ramsay T, Betancourt MT, Kovacs MJ. Low prevalence of JAK2 V617F mutation in patients with first unprovoked venous thromboembolism. British Journal of Haematology. 155(4):511-513, 2011.

Latella J, Desmarais S, Miron MJ, Roussin A, Joyal F, Kassis J, Solymoss S, Desjardins L, Ginsberg JS, Kahn SS. Relation between D-dimer level, venous valvular reflux and the development of post-thrombotic syndrome after deep vein thrombosis. J Thromb Haemost; 8(10):2169-2175, Oct 2010.

Rodger MA, Le Gal G, Carrier M, Betancourt MT, Kahn SR, Wells PS, Anderson DA, Lacut K, Chagnon I, Solymoss S, Crowther M, Perrier A, White R, Vickars L, Ramsay T, Kovacs MJ. Serum lipoprotein (a) levels in patients with first unprovoked venous throboembolism is not associated with subsequent risk of recurrent VTE. Thromb Res; 126(3):222-226, Sep 2010.

Kovacs JM, Kahn SR, Wells PS, Anderson DA, Chagnon I, Le Gal G, Solymoss S, Crowther M, Perrier A, Ramsay T, Betancourt MT, White RH, Vickars L, Rodger MA. Patients with a first symptomatic unprovoked deep vein thrombosis are at higher risk of recurrent venous thromboembolism than patients with a first unprovoked pulmonary embolism. J Thromb Haemost; 8(9):1926-1932, Sep 2010.

Le Gal G, Kovacs MJ, Carrier M, Do K, Kahn SR, Wells PS, Anderson DA, Chagnon I, Solymoss S, Crowther M, Righini M, Lacut K, White RH, Vickars L, Rodger M. Risk of recurrent venous thromboembolism after a first oestrogen-associated episode. Date from the REVERSE cohort study. Thromb Haemost; 104(3):498-503, Sep 2010.

Hull RD, Pineo GF, Brant R, Liang J, Cook R. Solymoss S, Poon MC, Raskob G; LITE Trial Investigators. Home therapy of venous thrombosis with long-term LMWH versus usual care: patient satisfaction and post-thrombotic syndrome. Am J Med; 122(8):762-769.e3, Aug 2009.

Le Gal G, Kovacs MJ, Carrier M, Do K, Kahn SR, Wells PS, Anderson DA, Chagnon I, Solymoss S, Crowther M, Righini M, Perrier A, White RH, Vickars L, Rodger M. Validation of a diagnostic approach to exclude recurrent veous thromboembolism. J Thromb Haemost; 7(5):752-759, May 2009.

Neville C, Rauch C, Kassis J, Solymoss S, Joseph L, Belisle P, Levine JS, Fortin PR. Antiphospholipid antibodies predict imminent vascular events independently from other risk factors in a prospective cohort. Thromb Haemost; 101(1):100-107, Jan 2009.

Kahn S, Shrier I, Julian JA, Ducruet T, Arsenault L, Miron MJ, Roussin A, Desmarais S, Joyal F, Kassis J, Solymoss S, Desjardins L, Lamping D, Johri M, Ginsberg JS. Determinants and time course of the postthrombotic syndrome after acute deep vein thrombosis. Ann Int Med. 149:698-707, 2008.
 
Rodgers M, Kahn SR, Wells PS, Anderson DA, Chagnon I, Le Gal G, Solymoss S, Crowther M, Perrier A, White R, Vickars L, Ramsay T, Betancourt M, Kovacs M. Identifying low risk unprovoked thromboembolism patients who can discontinue long term oral anticoagulants. CMAJ. 179:417-426, 2008.
 
Solymoss S. Cancer and thrombosis: Recent advances. Current Oncology. 15(6):302-303, 2008.
 
Kearon C, Julian J, Kovacs M, Anderson D, Wells P, MacKinnon B, Weitz J, Dolan S, Crowther M, Geerts W, Turpie G, Solymoss S, van Nguyen P, Demers C, Kahn S, Kassis J, Rodger M, Hambleton J, Gent M, Ginsberg J. Influence of thrombophilia on risk of recurrent venous thromboembolism while on warfarin: Results from a randomized trial. Blood. 112: 4432-4436, 2008.
 
Kahn SR, Shbaklo H, Lamping DL, Holcroft CA, Shrier I, Miron MJ, Roussin A, Desmarais S, Joyal F, Kassis J, Solymoss S, Desjardins L, Johri M, Ginsberg JS. Determinants of health-related quality of life during the two years following deep venous thrombosis. J Thromb Haem; 6(7):1105-1112, 2008.
 
Abou-Nassar K, Kovacs MJ, Kahn SR, Wells P, Doucette S, Ramsay T, Clement AM, Khurana R, Mackinnon K, Blostein M, Solymoss S, Kingdom J, Sermer M, Rey E, Rodger M. The effect of dalteparin on coagulation activation during pregnancy in women with thrombophilia: A randomised trial. Thromb Haemost. 98: 163-71, 2007.